I use a 3rd party DLL in my VB.NET project (VS2005) that responds to slow and give wrong values in debug mode. In run-time mode everything works as expected.

I do understand that there are something going on in the debug mode which makes the DLL communication slow. This behavior makes it hard to debug the application correctly.

Is there any way to force VS to communicate with the DLL in "run-time" mode during debugging but let the rest of the project be in control of the debugger?

I found a setting that resolved my issue:

Project Properties > Debug > Enable Debuggers > select "Enable unmanaged code debugging".

Now the DLL communication flowed smoothly. The DLL I use is a middleware between my app and a USB device. There is no Debug/Release version of the DLL.